Over the past 24 hours, several key developments have emerged that can significantly impact fantasy football lineups for Week 10 of the 2024 NFL season.

### Quarterback Decisions

One of the standout recommendations is to start Sam Darnold of the Minnesota Vikings. Darnold is facing the Jacksonville Jaguars, a team that has allowed the most fantasy points to quarterbacks this season. Given this favorable matchup, Darnold is expected to have one of his best games of the season.

### Running Back Considerations

For running backs, Javonte Williams of the Denver Broncos is advised to be sat. Williams has seen his playing time decline in recent weeks, and his upcoming matchup against the Kansas City Chiefs does not look promising for significant running opportunities.

### Injury Updates

Injuries continue to play a crucial role in fantasy football decisions. Here are some key updates:

- **Christian McCaffrey**: The San Francisco 49ers running back is likely to return in Week 10 against the Tampa Bay Buccaneers but may not play a full allotment of snaps due to the risk of reinjury. This makes it wise to hold onto backup running backs Jordan Mason and Isaac Guerendo for now.

- **Chris Olave**: The New Orleans Saints wide receiver is expected to miss multiple weeks, including Week 10, due to a concussion. Rookie Mason Tipton will continue to see heavy snaps in Olave's absence.

- **Deebo Samuel Sr. and Jauan Jennings**: Both San Francisco 49ers wide receivers are dealing with injuries but are trending in the right direction. Samuel (oblique, rib) and Jennings (hip) were listed as limited in practice, but if they are active, they are worth starting. Jennings, in particular, could see significant volume in the passing attack.

- **DeVonta Smith**: The Philadelphia Eagles wide receiver did not practice on Wednesday due to a hamstring injury. The severity is currently unknown, but this is a situation worth monitoring closely as soft tissue injuries can linger.

### Wide Receiver Rankings

In terms of wide receiver rankings, several players are highlighted as must-starts or those to keep an eye on. Ja’Marr Chase, Justin Jefferson, and Garrett Wilson top the list, while players like Deebo Samuel and A.J. Brown are also significant if they are active and healthy.

### General Strategy

When making start-sit decisions, it is crucial to consider the matchup, recent performance, and injury status of each player. Even top performers can have off-days, and underappreciated players can unexpectedly shine. Tools like PFF rankings, WR/CB matchup charts, and weekly projections can provide valuable insights to help make informed decisions.

By staying updated on these developments, fantasy football managers can make better-informed decisions to optimize their lineups for Week 10.