Welcome to another episode of BeeWellwithMS. In this episode, I have the pleasure of sitting down with Dr. Antonio Scalfari, a leading neurologist and researcher in the field of Multiple Sclerosis (MS). Dr. Scalfari is a consultant neurologist at the tertiary centre for the management of MS and neuro-inflammatory diseases and an Honorary Senior Clinical Lecturer at Imperial College London. He has authored several scientific articles and participates often as a speaker at international conferences and webinars.Our conversation revolves around the fascinating topic of aging and the impact it has on our brain health, particularly for those living with MS. We delve into the mechanisms of aging and what we can do to slow and even reverse the aging process. Dr. Scalfari shares actionable protocols and tips that you can incorporate into your daily life, giving you the knowledge and tools to offset the biological effects of aging.We explore topics such as the Mediterranean diet, the existence of the longevity gene, and whether aging is a disease that we can bio-hack. We also discuss the impact of aging on muscle mass, grip strength, and uric acid antioxidant levels, as well as the age of peak MS disease development.Dr. Scalfari provides insight into the process of natural MS progression and introduces the concept of smouldering MS. We also touch on immunosenescence, the process of aging of immune and brain cells, and the important process of remyelination of the central nervous system.The episode concludes with Dr. Scalfari sharing intermittent fasting protocols and actionable steps to help offset the effects of aging. By the end of this episode, you will have a deep understanding of the biology of aging and the tools you need to offset its effects on your brain health, whether you live with MS or not.


Episode recording timeline: 00:00- 2:44 min Intro of the whole episode and Dr Scalfari Bio 2: 44 min What does the brain health mean to Dr Scalfari and his family 4:40 min Is ageing a disease and can we bio- hack the aging process? 6:45 min What Mediterranean people do to expand their life longevity? 7:40 min Does the longevity gene exist? 8:12 min Are people with MS are born to have or acquired to have MS? 10:06 min Discussion about Sarcopenia( Low muscle mass that happens with ageing process) and evidence of grip strengh( potential biomarker of aging) and Uric acid antioxidant 14:48 min: what is the peak age of of developing MS disease 20:49: min How MS brain age? 24: 20 min How to modify natural ageing process living with MS 26:43 min Immunosenesence- ageing of immune and brain cells 28:24 min Remyelination process of the central nervous system 29:49 min When people with MS age do they have less MS disease activity? 32:59 min Smouldering MS concept, what is it and why it is important ? 46:25 min Intermittent fasting protocols.