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12 JUN 2025 · Utilising novel organoid perturbation and Artificial Intelligence (AI) platforms, the aim is to create a comprehensive dataset to fuel foundational drug discovery models and
a collaboration to build the foundation of a single cell atlas, focused on understanding and elucidating cancer plasticity in response to therapies. The collaboration will catalyse an ambitious future phase to develop a cancer plasticity atlas encompassing hundreds of millions of cells.
Dr. Mathew Garnett, Group Leader at the Sanger Institute, and Prof. Fabian Theis, Director of the Computational Health Center at Helmholtz Munich and Associate Faculty at the Sanger Institute, will be the principal investigators in the collaboration.
5 JUN 2025 · How do we get diverse samples into Sanger? We chat to the Sample Management team for the Tree of Life programme at Sanger to understand more about how we manage to get samples of eukaryotic organisms for sequencing from all around the world.
4 JUN 2025 · UK babies with a specific mix of gut bacteria have a lower risk of being hospitalised for viral lower respiratory tract infection in the first two years of life.
A baby's makeup of gut bacteria — their microbiome — which starts to form as soon as they are born, could help protect against viral infections later in childhood, a new study suggests.
As part of the largest study of UK baby microbiomes to date, researchers at the Wellcome Sanger Institute and University College London (UCL) found that babies with a specific mix of gut bacteria at one week old, which was only found in some babies born vaginally, were less likely to be hospitalised for viral lower respiratory tract infections (vLRTI) in the first two years of life.
27 MAY 2025 · With the World Health Organization (WHO) recently adopting an agreement on pandemic preparedness, we spoke with John Sillitoe, Director of the Wellcome Sanger Institute’s Genomic Surveillance Unit, to find out more about the role data and genomics can play in preventing future outbreaks.
Genomic data are already transforming how we understand infectious diseases, but the true potential lies in how data are used. A thoughtful, integrated approach to data — involving not just collection, but timely analysis, sharing, and application — will be key to strengthening public health systems before the next pandemic strikes. At the Sanger Institute, the Genomic Surveillance Unit (GSU) is contributing to this goal by supporting data-informed public health responses through collaborative research and capacity-building projects.
23 MAY 2025 · The Academy of Medical Sciences Fellowship recognises Sam Behjati’s work on improving diagnosis and treatments of childhood cancers.
Sam joins a group of 54 exceptional biomedical and health scientists elected as Fellows to the Academy in 2025. This honour recognises remarkable contributions to advancing medical science, groundbreaking research discoveries and translating developments into benefits for patients and the wider public.
22 MAY 2025 · Professor Muzlifah “Muzz” Haniffa, Head of https://www.sanger.ac.uk/programme/cellular-genomics/ at the Wellcome Sanger Institute, takes us on a ride of serendipitous discovery both personal and professional. She leads us to a new ambitious vision that will apply learnings from space, time and context, much like life itself, to cells and tissue ecosystems that impact health and disease.
17 MAY 2025 · A child’s genetic ancestry and their parents’ smoking habits are correlated with the rate and type of new genetic variants that occur in their genome, offering insights into a key biological process that affects genetic disease and human evolution.
Ancestry and lifestyle choices of parents may affect the rate and type of new genetic changes that arise in their children, new research has found.
Published in Nature Communications (15 May), researchers from the Wellcome Sanger Institute, the University of Cambridge and their collaborators analysed whole-genome sequence data from 10,000 parent-child ‘trios’. They studied the influence of ancestry, common genetic variants and environmental factors on the rates and types of de novo mutations (DNMs) – genetic changes that arise in the egg or sperm and are passed down to offspring.
8 MAY 2025 · Research uncovers insights into how particular cancer cells develop and spread throughout the lung.
The ‘cell of origin’ of the second most common lung cancer and the way that it becomes dominant in the lung have been discovered, in a new study in mice and humans from researchers at the Wellcome Sanger Institute, UCL, and the University of Cambridge.
The study, https://www.science.org/doi/10.1126/science.ads9145, revealed that a population of basal cells found in the windpipe outcompete other cell types and become dominant, eventually invading and occupying large areas of the lung.
6 MAY 2025 · In this seventh part of https://www.sanger.ac.uk/innovation/case-studies/ we spoke to Dr Trevor Lawley, Senior Group Leader at the Wellcome Sanger Institute who works in the Parasites and Microbes Programme. Trevor’s is the story of turning basic, fundamental research into innovative science with potential to treat a broad range of human diseases.
Innovation takes many forms – from a tweak that improves technology, all the way to the development of new medicines. Translating science is about applying research, moving it beyond the lab, or closing gaps in technologies so that it can be used to improve our lives. Trevor spoke to us about how he spotted those opportunities and co-founded the clinical company Microbiotica, how he’s building global collaborations with the International Fellows Scheme at Sanger and how the gut microbiomes of babies can give us insight into longer, healthier lives.
1 MAY 2025 · A previously unidentified type of mosquito has been found along the coast of Kenya and Tanzania, with potential implications for malaria surveillance and control.
This newly discovered mosquito, provisionally named the Pwani molecular form, belongs to the Anopheles gambiae complex — a group that includes some of the world’s most important malaria vectors.
This discovery, published (16 April) in https://onlinelibrary.wiley.com/doi/10.1111/mec.17762, was the result of a collaboration between the Wellcome Sanger Institute, the University of Glasgow, and the Ifakara Health Institute in Tanzania. The team’s work reveals the presence of a genetically divergent mosquito that could have profound implications for malaria vector surveillance and insecticide-based control strategies in the region.
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| Author | Wellcome Sanger Institute |
| Organization | Wellcome Sanger Institute |
| Categories | Life Sciences , Medicine , Nature |
| Website | www.sanger.ac.uk |
| communications@sanger.ac.uk |
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