Buck and Dr. Nathan Bryan delve into the pivotal role of nitric oxide in human physiology, with a particular focus on cardiovascular health and aging. Dr. Bryan breaks down the body’s nitric oxide production processes, how everyday lifestyle choices impact its levels, and what happens when there’s a deficiency. He also explores the surprising connection between oral hygiene and nitric oxide, the risks associated with proton pump inhibitors, and the promise of emerging products designed to boost nitric oxide levels. Additionally, Dr. Bryan addresses genetic factors such as MTHFR polymorphisms that can impact nitric oxide synthesis, shedding light on their broader implications for health and longevity. 00:00  The Role of Nitric Oxide in Human Physiology 02:54 Age-Related Decline of Nitric Oxide and Cardiovascular Health 05:49 Understanding Nitric Oxide Production Pathways 09:03 The Impact of Oral Health on Nitric Oxide Levels 12:11 Proton Pump Inhibitors and Their Effects on Nitric Oxide 15:12 Pharmaceutical Approaches to Increase Nitric Oxide 18:03 Innovations in Nitric Oxide Delivery Systems 21:25 The Role of Nitric Oxide as a Hormone 23:02 Nitric Oxide in COVID-19 Treatment 25:58 MTHFR Gene and Nitric Oxide Production 29:05 Cardiovascular Disease and Nitric Oxide 31:53 Safety and Regulation of Nitric Oxide 34:05 Cholesterol Myths and Nitric Oxide's Importance