Human skin map gives recipe to build skin and could help prevent scarring
Oct 16, 2024 ·
8m 45s
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Description
Prenatal human skin atlas and organoid will accelerate research into congenital diseases and lead to clinical applications for regenerative medicine. For the first time, researchers have created a single cell...
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Prenatal human skin atlas and organoid will accelerate research into congenital diseases and lead to clinical applications for regenerative medicine.
For the first time, researchers have created a single cell atlas of prenatal human skin to understand how skin forms, and what goes wrong in disease.
Researchers from the Wellcome Sanger Institute, Newcastle University and their collaborators used single cell sequencing and other genomics techniques to create the atlas and uncover how human skin, including hair follicles, is formed. These insights could be used to create new hair follicles in regenerative medicine and skin transplants for burn victims.
In the study, published today (16 October) in Nature, the team also created a ‘mini organ’ of skin in a dish with the ability to grow hair. Using the organoid, they showed how immune cells play an important role in scarless skin repair, which could lead to clinical applications to prevent scarring after surgery, or scarless healing after wounding.
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For the first time, researchers have created a single cell atlas of prenatal human skin to understand how skin forms, and what goes wrong in disease.
Researchers from the Wellcome Sanger Institute, Newcastle University and their collaborators used single cell sequencing and other genomics techniques to create the atlas and uncover how human skin, including hair follicles, is formed. These insights could be used to create new hair follicles in regenerative medicine and skin transplants for burn victims.
In the study, published today (16 October) in Nature, the team also created a ‘mini organ’ of skin in a dish with the ability to grow hair. Using the organoid, they showed how immune cells play an important role in scarless skin repair, which could lead to clinical applications to prevent scarring after surgery, or scarless healing after wounding.
Information
| Author | Wellcome Sanger Institute |
| Organization | Wellcome Sanger Institute |
| Website | - |
| Tags |
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